Author

Madhu Babu Gajula Balija

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Open access Aug 2026

Kinase-specific phosphorylation of tau outside the amyloid core encodes fibril fold selection

It is demonstrated that kinase-specific phosphorylation outside the amyloid core can be sufficient to bias tau toward a defined fibril structure, establishing a direct mechanistic link between kinase specificity, post-translational modification, and tau strain formation.

Reshma Ramesh, Sambhasan Banerjee, Madhu Babu Gajula Balija et al. · bioRxiv · 0 citations