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Magdalena A. Sutcliffe

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Open access Aug 2026

Reversible epiblast regionalization determines differentiation potential of human pluripotent stem cells.

It is shown that loss of default neural differentiation capacity and failure to form brain organoids are linked to erosion of bivalent chromatin marks at developmental gene loci, independent of DNA methylation, driving acquisition of a posterior epiblast-like state and premature developmental gene expression.

Magdalena A. Sutcliffe, Eugenia Wong, S. Wingett et al. · 1 citation

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