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Author

Magnus S. Bauer

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Open access Jul 2026

De novo design of selective kinase modulators

Protein kinases are critical regulators of cellular signaling, but precise modulation of their activity remains challenging due to their high structural conservation. Here, we present de novo designed genetically encoded miniproteins capable of activating or inhibiting focal adhesion kinase (FAK) by directly targeting...

Magnus S. Bauer, Saurav Kumar, Mia S. Donald-Paladino et al. · 0 citations
Open access Jul 2026

De novo design of selective kinase modulators

Protein kinases are critical regulators of cellular signaling, but precise modulation of their activity remains challenging due to their high structural conservation. Here, we present de novo designed genetically encoded miniproteins capable of activating or inhibiting focal adhesion kinase (FAK) by directly targeting...

Magnus S. Bauer, Saurav Kumar, Mia S. Donald-Paladino et al. · 0 citations

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