Integrative Multi-Omics and Structure-based Analysis of DHODH Reveals its Therapeutic Potential in Colorectal Cancer
Dihydroorotate dehydrogenase (DHODH) is a mitochondrial enzyme involved in de novo pyrimidine biosynthesis and has emerged as a potential target in cancer metabolism and therapy. This study integrated transcriptomic analysis with structure-based drug discovery to investigate the biological significance and therapeutic...