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Author

Mahdia Rahman

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Open access Aug 2026

Discovery of PilU as a second type IV pilus retraction motor in Myxococcus xanthus

ABSTRACT Type IV pili (T4P) drive social (S) motility in Myxococcus xanthus through cycles of extension and retraction powered by the ATPases PilB and PilT. Although the canonical retraction ATPase PilT is essential for force generation, M. xanthus encodes four PilT-like paralogs whose contributions to motility remain...

Mahdia Rahman, K. Subedi, Andrea Harms et al. · 0 citations
May 2026

Discovery of PilU as a second Type IV pilus retraction motor in Myxococcus xanthus

It is shown that PilU is essential for productive T4P retraction, functioning as an accessory motor that enhances or stabilizes PilT-driven force generation, and it is revealed that PilU activity is modulated by environmental calcium and depends on a flexible C-terminal region that influences motor complex dynamics.

Mahdia Rahman, K. Subedi, Andrea Harms et al. · 0 citations

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