Hepatic ELOVL2 regulates sex differences in mouse heart omega-3 polyunsaturated fatty acid metabolism.
Premenopausal females have higher docosahexaenoic acid (DHA, 22:6n-3) levels than males, with elongation of very long chain fatty acids-like 2 (Elovl2) implicated in regulating these differences. We employed a liver-specific Elovl2-KO model to determine how hepatic ELOVL2 activity influences sex differences in DHA synt...