Author

Mahmoud Mostafa

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Open access Sep 2026

Nanosized Bilosomes as a Potential Platform for Improved Therapeutic Efficacy of Capecitabine Against Colon Cancer in Rats: Formulation, Evaluation, and Optimization

Background/Objectives: Colorectal cancer is a leading cause of global cancer-related mortality. Capecitabine, a 5-fluorouracil prodrug, effectively targets colorectal cancer but suffers from an extremely short half-life, requiring frequent administration. Bilosomes (membrane-stabilized bile salts) are vesicular systems...

Mahmoud Mostafa, Abd El Hakim Ramadan, A. El-Shenawy et al. · Pharmaceuticals · 0 citations

Open access Jul 2026

Metal-dependent cell death in doxorubicin-induced cardiotoxicity and mitigation by luteolin: Network pharmacology and experimental verification.

Findings support the involvement of ferroptosis and cuproptosis related signaling in DIC and highlight LUT, particularly in nanoliposomal form, as a promising cardioprotective strategy against anthracycline toxicity.

Amina A. Farag, W. E. El Gazzar, Mahmoud Mostafa et al. · Biomedicine & pharmacotherap... · 0 citations