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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Mai Sakai

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Open access Sep 2026

Systematic characterization of subchronic MK-801 administration across mouse strains identifies conserved synaptic alterations and a clear cognitive phenotype in C57BL/6J mice.

BACKGROUND The N-methyl-d-aspartate (NMDA) receptor hypofunction hypothesis is central to schizophrenia, yet pharmacological MK-801 models exhibit variability across strains and conditions. We systematically compared behavioral and synaptic phenotypes induced by subchronic MK-801 administration across commonly used mou...

Fumiko Yoshimachi, Minori Ikuta, K. Kimura et al. · 0 citations

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