Author

Maina Takahashi

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Open access Aug 2026

Cis glycan–glycan interactions organize membrane nanodomains that tune receptor signaling

The plasma membrane (PM) is generally viewed as organized by coordinated interactions among proteins and lipids, largely overlooking the cell’s most extensive surface chemistry, the glycan layer. Here, we directly detect specific cis glycan–glycan interactions using single-molecule imaging of 39 chemically synthesized...

Kenichi G. N. Suzuki, N. Komura, Sachi Asano et al. · Nature Communications · 0 citations

Open access Aug 2026

From structure to function: binding determinants of a miniaturised phage depolymerase and their immunological relevance in Klebsiella pneumoniae capsule degradation.

This study provides a comprehensive NMR and mutational analysis to characterise the mechanism of action of a miniaturised depolymerase, here mKP34gp57, targeting the clinically relevant K63 CPS, and shows by NMR that mKP34gp57 hydrolyses CPS with high efficiency through an endoglycosidase-retaining mechanism.

Ferran Nieto-Fabregat, Mario Privitera, Angela Marseglia et al. · International Journal of Bio... · 1 citation