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Maira Mirza

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Open access Sep 2026

Epigenetic perturbation unravels diverse origins, state conversions and de-differentiation of cortical astrocytes

DOT1L is established as a barrier between these astrocyte states, limiting differentiation of the astrocytes expressing phagocytosis marker genes, and lowering the DOT1L-mediated epigenetic barrier strongly favours appearance of astrocytes with limited phagocytosis properties and reactivation of progenitor programs.

Maira Mirza, Tobias Hohl, Camila L. Fullio et al. · 0 citations

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