Open access
Sep 2026
Dysregulated microRNA-mRNA networks in SOD1G93A mouse skeletal muscle reveal metabolic impairments in ALS.
It is shown that SOD1G93A drives an early, sustained miRNA signature that dampens glycolysis gene expression, which could promote the fast-to-slow fibre-type transition and exacerbate energy deficit in ALS muscle.
Libby Moody, Eleni Christoforidou, Greig Joilin et al.
· Disease Models & Mechanisms · 0 citations