Single-Cell Profiling of Apoptotic Resistance in Patient-Derived Xenografts and Primary Circulating Tumor Cells Using TetherChip.
Circulating tumor cells (CTCs) must escape the primary tumor and spread to distant organs through harsh, nonadherent blood, and lymphatic microenvironments, where over 99% perish. Some CTCs survive by resisting extracellular matrix (ECM) detachment-induced apoptosis (anoikis). CTC enumeration has already been directly...