Author

Makoto Murakami

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Open access Sep 2026

Lysophospholipase PNPLA7 is a critical checkpoint of phosphatidylcholine catabolism and turnover for skeletal muscle homeostasis.

Current evidence suggests that disturbed phosphatidylcholine (PC) turnover causes skeletal muscle dysfunction. However, the enzyme that converts lysophosphatidylcholine (LPC) to glycerophosphocholine (GPC), an irreversible checkpoint in PC catabolism, in skeletal muscle has remained unidentified. Here we show that PNPL...

Shoya Matsumoto, Heeyoon Seo, Y. Taketomi et al. · Cell Reports · 0 citations

Open access Sep 2026

PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity

In-depth spatial profiling identifies PLA2G2D as a TDLN-centred targetable immune checkpoint for cancer immunotherapy and identifies a specific population of macrophages that express high levels of the enzyme PLA2G2D in tumour-draining lymph nodes that is associated with poor prognosis in patients.

A. van Krimpen, Julie Y. Huang, Mike Eterman et al. · Nature · 0 citations

Open access Jul 2026

Lysyl-phosphatidylglycerol promotes cell-to-cell contact and biofilm formation of Staphylococcus aureus as a biofilm matrix component

Findings uncover a previously unrecognized structural role of extracellular phospholipids in biofilm architecture and suggest that targeting Lys-PG and its biosynthetic pathway represents a promising strategy for biofilm control.

Shinya Sugimoto, Keiichiro Hara, Y. Taketomi et al. · npj Biofilms and Microbiomes · 0 citations