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Author

Mamdouh F. A. Mohamed

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Sep 2026

Rationale design and synthesis of new quinazoline derivatives as DNA intercalators and topoisomerase II inhibitors.

In pursuit of novel anticancer agents with enhanced potency and selectivity, a new series of quinazoline-based derivatives was rationally designed, synthesized, and biologically evaluated as potential DNA intercalators and topoisomerase II (Topo II) inhibitors. Building upon a previously identified lead compound (6), s...

Amr S. Helmy, Mamdouh F. A. Mohamed, I. Eissa et al. · 0 citations
Open access Aug 2026

Exploration of novel hydroxamic acid-based candidates integrating chalcone scaffold cap as multitarget HDAC inhibitors: design, anti-prostatic cancer assessment, in silico docking and molecular dynamic simulation

The potential use of this compound for treating prostate cancer with bone metastasis is suggested, as its high affinity for HDACs and an atomistic standard 100 ns dynamic simulation supported the stability of these interactions.

Aya I. Abd El-hameed, Ibrahim M. Salem, Rasha M. Allam et al. · 1 citation

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