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Author

Mamede de Carvalho

2 papers indexed here

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Open access Sep 2026

Towards a deep-learning genomic tool for risk stratification and diagnostic support in sporadic ALS

A variety of common and rare genetic factors have been implicated in the development of amyotrophic lateral sclerosis (ALS), and the evidence is that a genetic component is present in most affected individuals. However, our current understanding of ALS genetics causally explains only a small proportion of sporadi...

Jia-Jing Hu, Oliver Pain, A. Al Khleifat et al. · 0 citations
Jul 2026

Evidence of stage-specific cognitive reserve effects on longitudinal cognition in amyotrophic lateral sclerosis.

About 50% of amyotrophic lateral sclerosis (ALS) patients develop cognitive-behavioural impairment, yet longitudinal studies diverge on onset and extent of decline. Cognitive reserve (CR) may modulate cognitive trajectories, although longitudinal evidence remains limited. We aim to characterize cognitive trajectories i...

Sara Simão, Miguel Oliveira Santos, M. Gromicho et al. · 0 citations

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