Sep 2026
CAPN1 promotes the progression of MLL-rearranged acute myeloid leukemia by suppressing SHP-1 and activating MAPK/ERK signaling pathway.
BACKGROUND The MLL-rearranged (MLL-r) acute myeloid leukemia (AML) represents a hematological malignancy with a dismal prognosis and a pressing demand for innovative therapeutic targets. CAPN1 is overexpressed in MLL-r AML and predicts poor prognosis, however, its roles in MLL-r AML remains unclear. METHODS Prognosti...
Jia-Yin Liu, Xu Cao, Yan Lu et al.
· Biochimica et Biophysica Act... · 0 citations