Active site engineering of recombinant human paraoxonase 1 for enhancing its catalytic efficiency against V-type nerve agent analog- Demeton S
Human Paraoxonase 1 (HuPON1) is a calcium-dependent serum enzyme with broad substrate specificity and therapeutic potential for detoxifying the organophosphates, including nerve agents. The V-type nerve agents are the most toxic synthetic organophosphates, with high lethality and environmental persistence, necessitatin...