Author

Manikandan Jayaraman

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Open access Oct 2026

Structural insights into the binding potential of natural therapeutic leads as antiviral agents against human Metapneumovirus nucleoprotein.

Human metapneumovirus (hMPV), a member of the family Pneumoviridae and the genus Metapneumovirus, is a prevalent cause of respiratory tract infections, leading to severe complications and even death. As of now, there are no approved specific antiviral drugs or vaccines for hMPV, underscoring the need for potential ther...

M. Jayaraman, M. Subbulakshmi, S. Nathar et al. · SAR and QSAR in environmenta... · 0 citations

Sep 2026

Deciphering the multitarget protective mechanisms of melatonin in cadmium-induced male reproductive toxicity via a computational approach.

Cadmium (Cd) is a widespread environmental contaminant that has a detrimental impact on male reproductive toxicity (MRT) due to oxidative stress, endocrine imbalance, inflammation and cell death processes. Despite the known potential of melatonin (MLT) to ameliorate the adverse effects of Cd on MRT, the exact molecular...

Uddesh Ramesh Wanjari, A. Mukherjee, M. Jayaraman et al. · Reproductive Toxicology · 0 citations

Jul 2026

A Computational Framework for Evaluating the Antidiabetic Potential of Medicinal Plant‐Derived Natural Products as Glucokinase Activators ( GCKAs ) for Type 2 Diabetes Mellitus ( T2DM )

Diabetes mellitus continues to be a significant global health burden due to its increasing prevalence, high cost of treatment expenditures, and limitations with current therapies. Glucokinase (GCK), a key regulator of glucose homeostasis in hepatocytes and pancreatic β‐cells, functions as a glucose sensor. Focusing...

Heyram Krishnakumar, Manikandan Jayaraman, D. Prabhu et al. · Journal of the Chinese Chemi... · 0 citations