Manimaran Vasanthan Nirmala E

Dapagliflozin-Loaded Nanostructured Lipid Carriers: Multivariate Optimization to Improve Oral Bioavailability

Dapagliflozin, a sodium–glucose co-transporter-2 (SGLT2) inhibitor used in the management of type II diabetes mellitus, suffers from poor aqueous solubility, slow dissolution, and pre-systemic metabolism that together limit its oral bioavailability. This study aimed to develop and optimize dapagliflozin-loaded nanostru...