Manoel Arcisio-Miranda

Dynamic clustering and Rab11-dependent regulation of voltage-gated proton channels at the plasma membrane.

AIMS Voltage-gated proton channels (HV1) play a key role in intracellular pH homeostasis in immune cells and have been implicated in the neurological damage after a stroke and the prognosis and malignancy of several tumors. Thus, the molecular mechanisms governing HV1 surface abundance are of great clinical significanc...