Author

Manuela Pintus

3 papers indexed here

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Nov 2025

DTI‐ALPS Primarily Reflects White Matter Diffusion Dispersion and Microstructural Heterogeneity in Neurodegeneration: Insights From Multi‐Modal MRI

1.1 Background The glymphatic system facilitates clearance of metabolic waste and pathological proteins from the brain, and its dysfunction has been implicated in neurodegenerative disease. The diffusion tensor imaging–analysis along the perivascular space (DTI-ALPS) has been proposed as a non-invasive MRI marker of gl...

L. Sacchi, Giovanni Farruggio, Giorgio Bocca et al. · bioRxiv · 1 citation

#diffusion models Open access Sep 2026

Assessing glymphatic role in the association between choroid plexus enlargement and white matter lesions load: The uncertain path through diffusion tensor imaging along the perivascular space (DTI-ALPS).

CP enlargement is associated with reduced DTI-ALPS and greater WML burden, but the contribution of glymphatic impairment remains uncertain, and alternative mechanisms may contribute to these findings.

L. Sacchi, Valentina Veronesi, Giorgio Bocca et al. · Journal of Alzheimer's Disea... · 0 citations

Open access Sep 2026

Microglia-derived extracellular vesicles uncover early alterations of inflammatory signaling in Alzheimer's disease.

Alzheimer's disease (AD) is increasingly recognized as a neurodegenerative disorder associated with chronic low-grade inflammation and age-related immune dysregulation. Microglial-derived extracellular vesicles (MDEVs) are emerging as important mediators of neuroimmune communication and potential biomarkers reflecting...

Chiara Bianchessi, M. Serpente, E. Ferri et al. · GeroScience · 0 citations