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Manuocher Shakib

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Open access Sep 2026

Integrative Multi-Omics and Structure-based Analysis of DHODH Reveals its Therapeutic Potential in Colorectal Cancer

Dihydroorotate dehydrogenase (DHODH) is a mitochondrial enzyme involved in de novo pyrimidine biosynthesis and has emerged as a potential target in cancer metabolism and therapy. This study integrated transcriptomic analysis with structure-based drug discovery to investigate the biological significance and therapeutic...

M. Sheikh, Md. Shahidul Islam, Manuocher Shakib et al. · 0 citations

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