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Author

Mao-Lin Li

2 papers indexed here

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Aug 2026

MitoGPS: A Mitochondrial DNA G-Quadruplex-Targeting Strategy for Tumor-Preferential Type I Photodynamic Therapy.

Photodynamic therapy (PDT) is a clinically promising, minimally invasive cancer treatment offering precise spatiotemporal control. However, achieving preferential tumor accumulation remains a critical challenge, which limits therapeutic efficacy and induces off-target toxicity. Here, we introduce the mitoGPS (mitochond...

Yu-Hui Guo, Yao-Hui Shi, Pei-Min Huang et al. · 0 citations
Aug 2026

Lead Optimization of Quinoline-Coumarin KRAS mRNA G-Quadruplex Ligands: Discovery of Non-Quaternary Ammonium Analogs as Translation Inhibitors.

This study designed and synthesized a series of nonquaternary ammonium analogs to investigate whether this structural motif could be removed without compromising KRAS rG4-related activity and identified Q29 as a promising lead for further development of KRAS translation inhibitors.

Mao-Lin Li, Wen-Wei Li, Wen-Li Fu et al. · 0 citations

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