Author

Mao-Sheng Cheng

2 papers indexed here

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Aug 2026

Discovery of novel quinazoline-containing ATR inhibitor for treatment of acute myeloid leukemia.

ATR is a core kinase in the DNA damage response pathway, primarily sensing replication pressure and double strand breaks, initiating cell cycle arrest, DNA repair, and apoptosis programs, and maintaining genomic stability. In this work, we validated that intervention in ATR function might regulate the progression of AM...

Xia-Yu Li, Jia-Yu Zhang, Jia-Yu Hao et al. · Bioorganic chemistry (Print) · 0 citations

Open access Sep 2026

A Pathway-Economical Synthesis Enabling Systematic Evaluation: Enantiodivergent Access to Aspidosperma Alkaloids Unlocks Divergent Antitumor Mechanisms

The difficulty in efficiently accessing to both enantiomers has long hampered the systematic evaluation of how chirality governs the bioactivity of natural products. We report a pathway-economical synthesis that addresses this challenge, unlocking enantiodivergent access to ten Aspidosperma alkaloids. The highlight o...

Xiang Li, Si-Meng Wang, Xiang He et al. · JACS Au · 0 citations