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Author

Marc Torrent

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Review Open access Sep 2026

Antimicrobial Peptides Beyond the Petri Dish: Translational Barriers to Therapeutic Development

Antimicrobial peptides (AMPs) are promising antibiotics with rapid bactericidal mechanisms, broad-spectrum activity, and efficacy against drug-resistant pathogens. Yet, despite decades of research and development of many active AMPs, translation to the clinic remains limited. Although AMPs kill bacteria efficiently u...

Marc Torrent · 0 citations
Open access Sep 2026

Seven amino acids gate transcriptional activation by a minimal MarA Helix-turn-helix DNA-binding domain

Prokaryotic transcription factors (TFs) lie at the core of antimicrobial resistance, controlling genes that let bacteria survive antibiotic exposure. The AraC/XylS family of TFs is defined by a ∼99-residue DNA-binding domain composed of two helix-turn-helix (HTH) motifs. While this two-motif architecture is considered...

Marina Corbella, Ariadna Serrano, Roberto Bello-Madruga et al. · 0 citations

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