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Author

Marcelo Wendt

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Open access Oct 2026

Synthesis and In Silico and In Vitro Antitumor Potential of Novel Organochalcogens Derived from Azidothymidine and 2,4,6-Trichloro-1,3,5-triazine

The preparation of a new class of organochalcogen compounds derived from arylchalcogeno aminothymidine (ACAT) and 2,4,6-trichloro-1,3,5-triazine is described. The compounds were obtained in good yields via aromatic nucleophilic substitution reactions between ACAT derivatives and the triazine ring. The developed proto...

Nayra Salazar Rocha, Sidne Rodrigues da Silva, Brenda Bomm Carvalho et al. · 0 citations
Open access Oct 2026

Combination of Organoselenium-Loaded Nanoparticles and Conventional Chemotherapeutics Synergistically Enhances Antitumor Efficacy and Modulates Multidrug Resistance: An In Vitro Study

Background/Objectives: Cancer causes high premature death worldwide, with 35 million new cases expected by 2050. Multidrug resistance (MDR), driven by genetic and epigenetic changes, hampers chemotherapy. In this study, polymeric nanoparticles (NPs) were formulated with an organoselenium nucleoside analogue (AFAT-Se) t...

Bruna Fracari Do Nascimento, Bianca Costa Maia-do-Amaral, Taís Baldissera Pieta et al. · 0 citations

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