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Author

Marco Bozzali

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Review Open access Sep 2026

Cerebral amyloid angiopathy-related inflammation and amyloid-related imaging abnormalities: Common magnetic resonance imaging findings and shared diagnostic clues – A narrative review

Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a clinical and neuroradiological manifestation reported in CAA patients as autoimmune encephalopathy. Its pathomechanisms are still incompletely understood, and its similarities with amyloid-related imaging abnormalities (ARIA) described in clinical trials...

M. Zedde, F. Piazza, G. Boulouis et al. · 0 citations
Nov 2025

DTI‐ALPS Primarily Reflects White Matter Diffusion Dispersion and Microstructural Heterogeneity in Neurodegeneration: Insights From Multi‐Modal MRI

Factor analysis indicated that DTI-ALPS clustered with MA and ODI rather than forming a distinct factor, suggesting that DTI-ALPS primarily reflects WM diffusion dispersion and heterogeneity rather than glymphatic flow in the context of neurodegeneration.

L. Sacchi, Giovanni Farruggio, Giorgio Bocca et al. · 1 citation
Sep 2026

Toward harmonized reporting of Alzheimer’s disease biomarkers in clinical practice

The principles of harmonized reporting for Alzheimer’s disease biomarkers and a structured framework for standardized clinical neurochemistry reports are discussed and a structured framework for standardized clinical neurochemistry reports is proposed.

L. Agnello, Andrea Pilotto, L. Gaetani et al. · 0 citations
Open access Sep 2026

T1 mapping in Alzheimer’s disease: a quantitative MRI study with amyloid-PET correlation

Quantitative T1 mapping (qT1) is a magnetic resonance imaging (MRI) biomarker of brain microstructural changes; however, its application in Alzheimer disease (AD) remains limited. We compared cortico-limbic qT1 values between patients with AD and healthy controls (HCs) and examined their relationship with amyloid burde...

L. Gualco, N. Montobbio, M. Losa et al. · 0 citations
Open access Jul 2026

Structural MRI signature predicts tau staging in Alzheimer's disease

Evidence is provided that multiregion T1‐MRI patterns can inform on tau‐PET burden in AD and may support approximate tau staging when tau‐PET is unavailable, especially in subjects with more advanced tau burden.

Martina Pulze, S. Garbarino, L. Lorenzini et al. · 0 citations
#diffusion models Open access Sep 2026

Assessing glymphatic role in the association between choroid plexus enlargement and white matter lesions load: The uncertain path through diffusion tensor imaging along the perivascular space (DTI-ALPS).

CP enlargement is associated with reduced DTI-ALPS and greater WML burden, but the contribution of glymphatic impairment remains uncertain, and alternative mechanisms may contribute to these findings.

L. Sacchi, Valentina Veronesi, Giorgio Bocca et al. · 0 citations
Open access Jul 2026

Stage-dependent effects of cognitive reserve on memory and brain structural integrity across the spectrum from healthy aging to Alzheimer’s disease

Findings support a stage-dependent model of CR, characterized by an additive protective role in healthy aging, patterns consistent with compensatory recruitment in early cognitive decline, and a possible loss of reserve effectiveness beyond a critical neuropathological threshold.

Laura Serra, Sabrina Bonarota, Giulia Caruso et al. · 0 citations

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