Open access
Aug 2026
Overcoming immune checkpoint inhibitor-mediated T-cell exhaustion with a TCR β chain-directed selective dual T-cell activator
Administration of anti-PD-1 with a bifunctional fusion molecule, anti-TCRβ-IL-2 followed by anti-PD-1 greatly enhanced anti-tumor efficacy leading to tumor cures and long-term protection in several murine models resistant to ICI.
Shantel Angstadt, Lucas A. Horn, Kristen Fousek et al.
· Journal of Experimental &... · 0 citations