Marcus Saarinen

Systematic identification of p11 as a signaling modulator across the GPCRome

The microprotein p11 (S100A10) is a ubiquitously expressed molecular scaffold that is known to be required for behavioral responses to certain antidepressants, presumably through its effect on G protein–coupled receptor (GPCR)–mediated signaling. Here, we demonstrate that p11 recruitment to GPCRs is promoted by an acti...