Maren Hinz

Targeting the AcrAB-TolC efflux pump by small molecules selectively addressing the outer membrane factor TolC

Background Gram-negative bacteria express several efflux pump complexes extruding a broad spectrum of antibiotics. The major efflux pump in E. coli is the AcrAB-TolC complex that expels a broad spectrum of antibiotics from the bacterium, resulting in impaired efficacy of these drugs. Therefore, the inhibition of efflux...