Marene H. Hardonk

Voluntary physical activity modulates brain ΔFOSB and alters co-activation networks in male and female mice.

Regular physical activity promotes brain health, yet the underlying mechanisms remain incompletely understood. Repetitive activation of neurons results in accumulation of the nuclear transcription factor ΔFOSB, a long-lived splice variant of FOSB. Long-term voluntary wheel running (VWR), a behavioral paradigm that mimi...