Author

Margarita Gutova

3 papers indexed here

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Open access Oct 2026

Intranasal L-MYC Neural Stem Cells Restore Neurovascular and Neuroimmune Homeostasis After TBI via CX3CL1 Upregulation and ICAM-1 Downregulation

Evidence is provided that a single intranasal dose of LMNSC01 can reprogram chronic neuroimmune and neurovascular dysfunction after TBI in both sexes and supports the translational development of non-invasive intranasal LMNSC01 therapy for TBI.

Brecken Enright, Jeffrey P. Cheng, V. Adhikarla et al. · bioRxiv · 0 citations

Open access Sep 2026

Patient-Derived Glioma Models Preserve Tumor Heterogeneity and Identify Stearoyl-CoA Desaturase1 (SCD1) as a Candidate Biomarker for Precision Immunotherapy

Background Pediatric and adult brain tumors, including glioblastoma, astrocytoma, ependymoma, and medulloblastoma, remain associated with poor prognosis despite advances in surgery, radiation, and chemotherapy. Therapeutic resistance, tumor heterogeneity, and treatment-related toxicity highlight the need for clinically...

Margarita Gutova, Eric Ma, H. Natri et al. · bioRxiv · 0 citations

Open access Aug 2026

Extracellular Vesicles Derived from L-MYC Neural Stem Cells Mediate Neuroprotection in 3D Models of Chemotherapy- and Radiation-Induced Neurotoxicity

Background/Objectives Cancer survivors frequently experience long-term neurocognitive impairments following chemotherapy and cranial irradiation, yet experimental models that enable mechanistic investigation of therapy-induced neurotoxicity at the transcriptional level remain limited. This study aimed to develop a huma...

Lance G. A. Nunes, Isabella Vasquez, Brecken Enright et al. · bioRxiv · 0 citations