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Author

Margus Varjak

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Open access Aug 2026

Pyridin-3-carbohydrazide strongly impairs Mayaro and Chikungunya virus replication in vitro

The data suggest that P-3-C exhibits a potential multitarget mechanism of action and highlight its antiviral activity against different alphavirus strains; however, this efficacy could be dependent on the cell line used.

N. Contreras, N. Cassani, Mikaela dos Santos Marinho et al. · 0 citations
Open access Aug 2026

Expanding Reverse Genetics of Positive-Strand RNA Viruses: Optimised Rescue Platforms and Construction of a Novel Fluorescent Reporter Nidovirus

It is demonstrated that a potent constitutive promoter system and a hammerhead ribozyme enhance the efficiency of positive-sense RNA virus rescue using CPER, and may support applications requiring efficient recovery of low fitness mutants and diverse mutational libraries and barcoded virus populations.

James R. Potter, Helen Mostafavi, A. Amarilla et al. · 0 citations

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