Review
Open access
Aug 2026
The expanded universe of thrombin: a comprehensive review of its hemostasis-independent roles and structure-function relationships
The molecular basis of thrombin’s versatility is explored, focusing on its allosteric regulation by sodium ions, its two anion-binding exosites, and its primary signaling mechanism via protease-activated receptors.
M. Sacco, S. Lancellotti, Antonietta Ferretti et al.
· Bleeding Thrombosis and Vasc... · 0 citations