Open access
Sep 2026
A Gene-Program Architecture of Mouse T cells
We present a gene-program framework for resolving mouse T cell heterogeneity across the immgenT atlas. On ∼800,000 T cells spanning lineages, organs, and immune challenges, we defined 200 reproducible gene programs, discovered by empirical Bayes matrix factorization approach and validated through a new deep learning ap...
Ziang Zhang, Tian-Ze Wang, Siba Smarak Panigrahi et al.
· bioRxiv · 0 citations