Maria Carmela Bonaccorsi di Patti

Computational Studies of the Dynamics of the Human Iron Exporter Ferroportin and Insight into the Role of Crucial Residues Involved in Pathogenic Mutations

Ferroportin (FPN/SLC40A1), the only known human iron exporter, plays a key role in iron homeostasis through an alternating access mechanism involving inward–open, occluded, and outward–open conformations. Pathogenic FPN mutations cause ferroportin–related iron overload, an autosomal dominant iron overload disease chara...