Hippocampal GluN2A knockdown differentially alters spatial exploration and behavioral performance in male and female rats
An AAV-mediated shRNA knockdown of GluN2A (GluN2A-kd) targeted to the hippocampus in adult Wistar rats is developed, avoiding developmental confounds and enabling the specific assessment of GluN2A function in mature neurons, position GluN2A as a key modulator of the precision and flexibility of spatial behavior require...