Review
Open access
Aug 2026
Decoding Synaptic Diversity: Molecular Architectures, Phase Transitions, and Shared Postsynaptic Failure in Alzheimer’s and Parkinson’s Disease
This review dissects the hierarchical organization of the synaptome, arguing that synaptic decay is not a generic process of attrition but a specific collapse of subsynaptic domains (SSDs) and trans-synaptic nanocolumns, considered here within the framework of the tetrapartite synapse.
G. Cipriano, Ivan Anchesi, Alessia Floramo et al.
· Cells · 0 citations