Human NLRC4 and CASP4 inflammasomes activate GSDMD-mediated killing of S. flexneri independently of macrophage pyroptosis and bacterial cardiolipin 2254736
Elimination of the infecting pathogen is a core function of the immune system. Macrophages are a crucial component of innate immunity against bacterial infections as they internalize and kill intracellular bacteria. Although macrophage restriction of some intracellular bacteria depends on inflammasomes, the speci...