: Tyrosine kinase inhibitor (TKI)-based chemotherapy-free strategies, combining dasatinib or ponatinib with the bispeci fi c monoclonal antibody blinatumomab, have substantially improved the response rates and outcome of adult patients with Philadel-phia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) [1 – 7]...
N. Peragine, M. Ansuinelli, G. Radice et al.· Blood Cancer Journal· 0 citations
Simple Summary Acute myeloid leukemia with NPM1 mutation (NPM1-mutated AML) is one of the most frequent and clinically relevant subtypes of acute myeloid leukemia. Over the last two decades, major advances in molecular biology have transformed the understanding of this disease and have directly influenced diagnosis, ri...
The mechanism whereby immunotherapy with Tregs/Tcons protects from GvHD while it preserves GvL in murine transplantation models and in transplanted leukemia patients is shown for the first time.
L. Ruggeri, Antonio Pierini, E. Urbani et al.· Blood Advances· 0 citations
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