Hereditary cancer syndromes as a model for precision oncology: the paradigms of HRD and MSI.
Hereditary cancer syndromes such as BRCA-associated and Lynch syndrome have provided a clinical framework for understanding the molecular underpinnings of homologous recombination deficiency (HRD) and microsatellite instability (MSI). These phenotypes have reshaped precision oncology by enabling biomarker-driven use of...