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Author

Mariami Kuljanishvili

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Open access Aug 2026

Cortical organoids reveal human-specific role of METTL5 in neurodevelopment via regulation of CHCHD2.

Overexpression of CHCHD2 in METTL5-KO NPCs rescued proliferation and partially rescued oxidative metabolism in NPCs and ventricle formation in organoids, highlighting a previously uncharacterized connection between CHCHD2, oxidative metabolism, and METTL5-mediated regulation of human neurogenesis.

Elena M Turkalj, Gugene Kang, I. Liu et al. · 0 citations