Author

Marieke Van Daele

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Open access Oct 2026

Fc‐Dependent Targeting of the GAS6–MERTK Axis With Monoclonal and Bispecific Antibodies Overcomes Drug Resistance Across EGFR Mutations in Exons 19, 20, and 21

ABSTRACT Resistance of lung cancer to EGFR‐targeting tyrosine kinase inhibitors (TKIs) like osimertinib frequently results from secondary mutations or activation of bypass signaling pathways. Re‐analysis of clinical data unveiled elevated expression of GAS6 and its receptor MERTK in lung cancer patients developing resi...

Suvendu Giri, Boobash-Raj Selvadurai, Nitin Gupta et al. · Advancement of science · 0 citations

Review Open access Aug 2026

Targeting EGFR in lung cancer: lessons in signal transduction and treatment-induced mutagenesis.

Current research into EGFR biology offers the potential to transform EGFR-positive NSCLC from a lethal disease into a chronic, manageable condition, as part of the discussion meeting issue 'Epidermal growth factor receptor after 40 years'.

Arturo Simoni-Nieves, Marieke Van Daele, Harrison B. Konsker et al. · Philosophical transactions o... · 1 citation