Open access
Oct 2026
Proximity of pre-mRNA 3' end processing and transcription termination is associated with enhanced gene expression.
It is shown that primary tumor cells depend on high CPSF73 and PCF11 levels, whereas metastatic cells are less sensitive, and the distance between 3' cleavage and termination is nearly halved in primary tumor cells compared with normal cells and becomes particularly short in oncogenes.
Agata Stępień, Deepshika Pulimamidi, Martyna Plens-Gałąska et al.
· EMBO Journal · 1 citation