Open access
Sep 2026
CReP-mediated control of eIF2α phosphorylation is a critical node in MYC-driven medulloblastoma
Medulloblastoma (MB) is the most common malignant pediatric brain tumor. The MYC‑amplified group 3 (G3) MB represents a high‑risk disease lacking effective therapies. A genetic screen identified the endoplasmic reticulum chaperone HSPA5 (BiP/GRP78) as a critical dependency in G3 MB. Its silencing induces apoptosis and...
Liliana Mirabal-Ortega, Sandra Majo, Lucie J. Taunay et al.
· Nature Communications · 0 citations