Mario A. Acuña

Caffeine attenuates Aβ-induced hippocampal dysfunction alongside changes in adenosine receptor-linked GABA handling and neuronal excitability.

Synaptic and circuit dysfunction in the hippocampus is an early feature of Alzheimer's disease, involving disturbances at both excitatory and inhibitory synapses. Adenosine receptors (ARs) regulate hippocampal glutamatergic and GABAergic signaling. Caffeine, a non-selective AR antagonist, has well-established neuroprot...