Mario Jug

Functional evaluation of loratadine–cyclodextrin complexes: comprehensive solid-state characterisation, biopharmaceutical assessment and stability profiling

Loratadine (LOR) is a poorly water-soluble antihistaminic drug whose solubility can be significantly enhanced in water and biorelevant media through inclusion complexation with β-cyclodextrins (β-CDs), as we have shown previously. In this work, we investigated the biopharmaceutical properties and chemical stability of...