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Author

Mario Milani

2 papers indexed here

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Review Open access Oct 2026

Pyridobenzothiazolones as non-nucleoside antivirals: From HCV polymerase inhibition to broad-spectrum antiviral agents.

Pyridobenzothiazolones (PBTZs) are tricyclic compounds originally investigated as chemotypes directed against viral RNA-dependent RNA polymerases. Following the first reports on hepatitis C virus (HCV) NS5B inhibition, medicinal chemistry optimization and mechanistic studies have expanded the antiviral profile of this...

Francesca Speranza, Claudia Massa, F. Cossu et al. · 0 citations
Open access Oct 2026

Structural dynamics and pH‐regulated membrane binding of the TRAF2‐NC trimer

Abstract Tumor necrosis factor receptor‐associated factor 2 (TRAF2) is a key adaptor in TNF receptor‐signaling that operates as a trimeric assembly. Here we investigate the structural and functional properties of a TRAF2 construct spanning the trimerization and receptor‐binding domains (TRAF2‐NC, residues 266–501). Acc...

F. Cossu, Serena Virili, Bianca Braggiotti et al. · 0 citations

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