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Author

Marion Russeau

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Open access Sep 2026

Sex-specific long-term alteration of hippocampal excitation/inhibition balance and behavior by transient caffeine exposure during synaptogenesis

Caffeine is the most widely consumed psychoactive substance worldwide, yet the long-term consequences of exposure during critical periods of brain development remain incompletely understood. Synaptogenesis represents a vulnerable window during which environmental factors can shape the maturation of neuronal circuits an...

Solen Rimbert, Jessica C. Pressey, Ferran Gomez-Castro et al. · 0 citations
Open access Sep 2026

Epileptic encephalopathy-related Kv2.1 mutants impair clustering but not neuronal excitability.

The voltage-gated potassium channel Kv2.1, encoded by the epileptic encephalopathy-associated gene KCNB1, is a primary driver of delayed-rectifier K+ currents in neurons. These currents contribute to high-frequency firing by preventing depolarization block due to Na+ channel inactivation. Wild-type (WT) channels are lo...

Anne-Lise Paupiah, Melvyn Ginisty, Capucine Gendre et al. · 0 citations
Open access Aug 2026

WNK-dependent phosphorylation of gephyrin tunes GABAA receptors at inhibitory synapses and modulates anxiety behavior.

It is shown that activation of WNK signaling stabilizes GABAARs at inhibitory synapses, while inhibition enhances receptor internalization, and position the WNK pathway as a master regulator of inhibitory synapse function.

Zaha Merlaud, Célia Delhaye, Margarida Nabais et al. · 0 citations

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