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Marios G. Krokidis

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Open access Sep 2026

APOE4 differentially alters lipid composition in extracellular vesicles from hiPSC-derived neurons of Alzheimer’s disease patients

Background The Apolipoprotein E4 (APOE4) is the most significant genetic risk factor for late-onset Alzheimer’s disease (AD), but the cellular mechanisms by which it increases vulnerability remain poorly understood. Lipids play a crucial role in membrane organization, vesicle trafficking, and inflammatory signaling in...

Marios G. Krokidis, Ram Sagar, Maja Mustapić et al. · 0 citations

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